Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities.

نویسندگان

  • Takeo Kasagami
  • In-Hae Kim
  • Hsing-Ju Tsai
  • Kosuke Nishi
  • Bruce D Hammock
  • Christophe Morisseau
چکیده

We investigated N-adamantyl-N'-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry letters

دوره 19 6  شماره 

صفحات  -

تاریخ انتشار 2009